Cancer chemoprevention locks onto a new polyamine metabolic target.
نویسنده
چکیده
Ornithine decarboxylase has a relatively long history as a target for cancer chemoprevention and chemotherapy. Plym Forshell et al. report new evidence (beginning on p. 140 in this issue of the journal) indicating that spermidine synthase, a fellow enzyme of ornithine decarboxylase in polyamine metabolism, is transactivated in part by the MYC gene and is a potential target for chemoprevention of B-cell lymphomas.
منابع مشابه
Polyamine metabolism and colorectal cancer 3. Influence of drugs on polyamine metabolism for CRC chemoprevention 4. Influence of nutritional factors on polyamine metabolism for CRC chemoprevention 5. Influence of dietary polyamines on CRC chemoprevention
Chemoprevention is the long-term use of different chemical agents, both synthetic and natural, to prevent or delay the onset of disease. Since colorectal cancer has a significant environmental component, it is an ideal disease in which to evaluate the potential benefits of chemopreventive agents. The polyamines, spermine, spermidine and putrescine have been involved in almost all the steps of c...
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ورودعنوان ژورنال:
- Cancer prevention research
دوره 3 2 شماره
صفحات -
تاریخ انتشار 2010